Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24030443 | 1.00 | KDM4E (0.43) | KDM4EMAPTTHRBEPHA2ERBB2 | |
| SCHEMBL24030211 | 1.00 | KDM4E (0.43) | KDM4EMAPTTHRBEPHA2ERBB2 | |
| SCHEMBL28653823 | 0.84 | ALDH1A1 (0.34) | SMN1; SMN2ENPP2 | |
| SCHEMBL28665563 | 0.84 | ALDH1A1 (0.34) | SMN1; SMN2ENPP2 | |
| SCHEMBL24030205 | 0.82 | FEN1 (0.49) | KDM4EMAPTTHRBPARP1PARP2 | |
| SCHEMBL24030429 | 0.82 | FEN1 (0.49) | KDM4EMAPTTHRBPARP1PARP2 | |
| SCHEMBL24030203 | 0.82 | FEN1 (0.49) | KDM4EMAPTTHRBPARP1PARP2 | |
| SCHEMBL30428386 | 0.79 | MEN1 (0.34) | SMN1; SMN2 | |
| SCHEMBL25238857 | 0.76 | EPHA2 (0.42) | KDM4EMAPTTHRBEPHA2ERBB2 | |
| SCHEMBL25295624 | 0.76 | EPHA2 (0.42) | KDM4EMAPTTHRBEPHA2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021228159-A1 | BRIDGED CYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, COMPOSITION CONTAINING SAME AND USE THEREOF | 上海纽思克生物科技有限公司 | 2021-11-18 | — | — | WO | disclosed |