Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.62 |
| ▸ | HPGDS | O60760 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26801774 | 0.90 | AR (0.65) | ARPGRCYP2C9CYP2D6S1PR3 | |
| SCHEMBL24031259 | 0.89 | AR (0.63) | ARHPGDSS1PR1S1PR3 | |
| SCHEMBL27027442 | 0.87 | AR (0.58) | ARPGRCYP2C9CYP2D6S1PR1 | |
| SCHEMBL24031267 | 0.87 | AR (0.71) | ARPGRCYP2C9CYP2D6KCNH2 | |
| SCHEMBL26801770 | 0.86 | AR (0.66) | ARCYP2C9S1PR3 | |
| SCHEMBL27027448 | 0.85 | AR (0.58) | ARPGRCYP2C9CYP2D6KCNH2 | |
| SCHEMBL27027440 | 0.85 | AR (0.57) | ARPGRCYP2C9CYP2D6KCNH2 | |
| SCHEMBL27027439 | 0.84 | AR (0.56) | ARPGRCYP2C9CYP2D6KCNH2 | |
| SCHEMBL26801765 | 0.83 | AR (0.74) | ARPGRCYP2C9CYP2D6S1PR1 | |
| SCHEMBL27295127 | 0.82 | AR (0.73) | ARPGRCYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231927-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-11-18 | — | — | WO | disclosed |