Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.71 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 7/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24031705 | 0.91 | AR (0.60) | ARS1PR3NPC1RAB9APGR | |
| SCHEMBL26801765 | 0.90 | AR (0.74) | ARS1PR3NPC1RAB9APGR | |
| SCHEMBL24031703 | 0.89 | AR (0.58) | ARS1PR3NPC1RAB9APGR | |
| SCHEMBL27295127 | 0.89 | AR (0.73) | ARNPC1RAB9APGRCYP2C9 | |
| SCHEMBL27027440 | 0.88 | AR (0.57) | ARS1PR3PGRCYP2C9CYP2D6 | |
| SCHEMBL24031270 | 0.88 | AR (0.56) | ARPGRCYP2C9CYP2D6KCNH2 | |
| SCHEMBL24031259 | 0.87 | AR (0.63) | ARS1PR3S1PR1S1PR2 | |
| SCHEMBL24031263 | 0.87 | AR (0.62) | ARS1PR3PGRCYP2C9CYP2D6 | |
| SCHEMBL27027448 | 0.87 | AR (0.58) | ARS1PR3PGRCYP2C9CYP2D6 | |
| SCHEMBL25898102 | 0.85 | AR (0.67) | ARS1PR3PGRCYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231927-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-11-18 | — | — | WO | disclosed |