Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.59 |
| ▸ | AR | P10275 | 7/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24031859 | 0.91 | CRBN (0.49) | CRBNARDDB1BRD9 | |
| SCHEMBL24031759 | 0.90 | CRBN (0.49) | CRBNARDDB1ESR1 | |
| SCHEMBL23129204 | 0.90 | CRBN (0.69) | CRBNARDDB1BTKITK | |
| SCHEMBL25900211 | 0.90 | CRBN (0.69) | CRBNARDDB1BTKITK | |
| SCHEMBL24031726 | 0.89 | CRBN (0.54) | CRBNARDDB1BTKBRD9 | |
| SCHEMBL26808203 | 0.88 | CRBN (0.54) | CRBNARDDB1BTKESR1 | |
| SCHEMBL26808846 | 0.88 | CRBN (0.54) | CRBNARDDB1BTKESR1 | |
| SCHEMBL26816393 | 0.88 | CRBN (0.54) | CRBNARDDB1ITKEGFR | |
| SCHEMBL24031399 | 0.88 | CRBN (0.54) | CRBNARDDB1BTKESR1 | |
| SCHEMBL23129206 | 0.87 | CRBN (0.59) | CRBNARDDB1ITKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231927-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-11-18 | — | — | WO | disclosed |