Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.49 |
| ▸ | AR | P10275 | 5/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.44 |
| ▸ | EP300 | Q09472 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.40 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24031374 | 0.91 | CRBN (0.59) | CRBNARBRD9DDB1 | |
| SCHEMBL25900147 | 0.86 | CRBN (0.62) | CRBNARDDB1 | |
| SCHEMBL24031917 | 0.84 | BRD9 (0.47) | CRBNARBRD9DDB1 | |
| SCHEMBL24031855 | 0.83 | CRBN (0.46) | CRBNARBRD9DDB1EP300 | |
| SCHEMBL26667224 | 0.82 | AR (0.75) | CRBNAR | |
| SCHEMBL24031858 | 0.82 | AR (0.75) | CRBNAR | |
| SCHEMBL24031759 | 0.81 | CRBN (0.49) | CRBNARDDB1GSPT1 | |
| SCHEMBL23129204 | 0.81 | CRBN (0.69) | CRBNARDDB1 | |
| SCHEMBL25900211 | 0.81 | CRBN (0.69) | CRBNARDDB1 | |
| SCHEMBL24031757 | 0.81 | CRBN (0.52) | CRBNARDDB1GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231927-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-11-18 | — | — | WO | disclosed |