Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21918068 | 0.89 | USP2 (0.43) | USP2SMN1; SMN2TSHRALOX15NR1H2 | |
| SCHEMBL2204005 | 0.87 | USP2 (0.49) | USP2SMN1; SMN2TSHRALOX15CYP4F2 | |
| SCHEMBL3164042 | 0.84 | USP2 (0.46) | USP2SMN1; SMN2TSHRALOX15CYP4F2 | |
| SCHEMBL485413 | 0.82 | HPGD (0.44) | USP2SMN1; SMN2CYP4F2CYP4A11NR1H2 | |
| SCHEMBL5765931 | 0.81 | USP2 (0.43) | USP2SMN1; SMN2TSHRALOX15CYP4F2 | |
| SCHEMBL21851983 | 0.79 | USP2 (0.44) | USP2SMN1; SMN2TSHRALOX15NR1H2 | |
| SCHEMBL16925368 | 0.78 | TSHR (0.42) | USP2SMN1; SMN2TSHRALOX15CYP4F2 | |
| SCHEMBL345212 | 0.78 | USP2 (0.41) | USP2SMN1; SMN2TSHRALOX15ATM | |
| SCHEMBL1880398 | 0.78 | USP2 (0.51) | USP2SMN1; SMN2TSHRALOX15CYP4F2 | |
| SCHEMBL24192631 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2CYP4F2CYP4A11NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11873307-B2 | Manufacture of compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2024-01-16 | — | — | US | disclosed |
| US-20210355134-A1 | MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355134-A1 | MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | PTPN5, PTPN7, PTPN1 | USP2 2274/4885SMN1; SMN2 3717/4885TSHR 3129/4885 |
| US-11873307-B2 | Manufacture of compounds and compositions for inhibiting the activity of SHP2 | PTPN5, PTPN7, PTPN1 | USP2 2274/4885SMN1; SMN2 3717/4885TSHR 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.