Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403223 | 1.00 | HDAC6 (0.76) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2402850 | 0.88 | HDAC6 (0.66) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2406270 | 0.88 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2406273 | 0.88 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2402847 | 0.88 | HDAC6 (0.66) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2404885 | 0.88 | HDAC6 (0.63) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2404883 | 0.88 | HDAC6 (0.63) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2403825 | 0.87 | HDAC6 (0.68) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL2403827 | 0.87 | HDAC6 (0.68) | HDAC6HDAC3HDAC1HDAC8HDAC5 | |
| SCHEMBL7935105 | 0.87 | HDAC6 (0.60) | HDAC6HDAC3HDAC1HDAC8HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212943-A1 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2011-09-01 | — | — | US | claimed |
| US-20170349540-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION | 2017-12-07 | — | — | US | disclosed |
| WO-2016018795-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-02-04 | — | — | WO | disclosed |
| US-20110212943-A1 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2011-09-01 | — | — | US | disclosed |
| US-20110212943-A1 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2011-09-01 | — | — | US | disclosed |
| US-20110212943-A1 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2011-09-01 | — | — | US | disclosed |
| WO-2010043953-A2 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349540-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC5 | HDAC6 10/4885HDAC3 5/4885HDAC1 1/4885 |
| US-20110212943-A1 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC7 | HDAC6 8/4885HDAC3 10/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.