Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.34 |
| ▸ | TET3 | O43151 | 2/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.32 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.32 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL2403413 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL5874335 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1GPR84 | |
| Malic Acid SCHEMBL218467 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1GPR84 | |
| Lactic Acid SCHEMBL23361751 | 0.81 | TP53 (0.46) | SMN1; SMN2GABRR1LMNA | |
| Malic Acid SCHEMBL21145183 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL2553128 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL2558660 | 0.80 | SMN1; SMN2 (0.75) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL2558655 | 0.80 | SMN1; SMN2 (0.75) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL4639678 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL786884 | 0.78 | SMN1; SMN2 (0.79) | SMN1; SMN2GABRR1LMNATET2TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011128699-A2 | NOVEL PROCESS | GENERICS [UK] LIMITED (GB) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011104555-A2 | NOVEL PROCESS | GENERICS [UK] LIMITED (GB) | 2011-09-01 | — | — | WO | disclosed |