Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.41 |
| ▸ | TET3 | O43151 | 2/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL2553128 | 1.00 | SMN1; SMN2 (0.68) | SMN1; SMN2GABRR1LMNAGPR84FFAR1 | |
| Malic Acid SCHEMBL2558655 | 0.91 | SMN1; SMN2 (0.75) | SMN1; SMN2GABRR1LMNAGPR84FFAR1 | |
| Malic Acid SCHEMBL2558660 | 0.91 | SMN1; SMN2 (0.75) | SMN1; SMN2GABRR1LMNAGPR84FFAR1 | |
| Malic Acid SCHEMBL17292408 | 0.88 | SMN1; SMN2 (0.79) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL786884 | 0.88 | SMN1; SMN2 (0.79) | SMN1; SMN2GABRR1LMNATET2TET3 | |
| Malic Acid SCHEMBL20394029 | 0.88 | SMN1; SMN2 (0.79) | SMN1; SMN2GPR84FFAR1TET2TET3 | |
| Malic Acid SCHEMBL28321609 | 0.88 | SMN1; SMN2 (0.58) | SMN1; SMN2GPR84FFAR1 | |
| Dodecylamine SCHEMBL7596422 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2GPR84FFAR1 | |
| Malic Acid SCHEMBL5874290 | 0.85 | SMN1; SMN2 (0.83) | SMN1; SMN2GABRR1LMNAGPR84TET2 | |
| Malic Acid SCHEMBL5874293 | 0.85 | SMN1; SMN2 (0.83) | SMN1; SMN2GABRR1LMNAGPR84TET2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| EP-3518878-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | SMN1; SMN2 3900/4885GABRR1 4360/4885LMNA 2196/4885 |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, SRRM2, IK | SMN1; SMN2 4150/4885GABRR1 2863/4885LMNA 1167/4885 |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CD44, PCNA | SMN1; SMN2 2681/4885GABRR1 4500/4885LMNA 2525/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | SMN1; SMN2 3725/4885GABRR1 3597/4885LMNA 3760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.