Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 14/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25095057 | 0.88 | CDK9 (0.37) | CDK9CCNT1KDM4EALDH1A1 | |
| SCHEMBL25095132 | 0.87 | CDK9 (0.39) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL30489991 | 0.85 | CDK9 (0.49) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL25635405 | 0.83 | CDK9 (0.39) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL25095184 | 0.83 | CDK9 (0.46) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL29799769 | 0.82 | CDK9 (0.36) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL24035526 | 0.82 | CDK9 (0.36) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL24031553 | 0.82 | CDK9 (0.36) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL25095225 | 0.82 | CDK9 (0.41) | CDK9CCNT1CCNKCDK1CDK4 | |
| SCHEMBL20861661 | 0.80 | CDK9 (0.62) | CDK9CCNT1CCNKCDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4141004-A1 | POLYCYCLIC AMIDE DERIVATIVE AS CDK9 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Suzhou Alphama Biotechnology Co., Ltd. (CN) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021227904-A1 | POLYCYCLIC AMIDE DERIVATIVE AS CDK9 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州阿尔脉生物科技有限公司 | 2021-11-18 | — | — | WO | disclosed |