Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184400 | 0.81 | ALDH1A1 (0.43) | HDAC10ALDH1A1ATMTDP1L3MBTL1 | |
| SCHEMBL19253450 | 0.78 | GRN (0.56) | ALDH1A1MEN1KMT2APTPN1PHGDH | |
| SCHEMBL31493114 | 0.74 | KDM4E (0.39) | L3MBTL1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31276998 | 0.73 | PHGDH (0.62) | ALDH1A1L3MBTL1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL24484133 | 0.73 | KDM4E (0.38) | MAPTPOLBMEN1KMT2APHGDH | |
| SCHEMBL31217429 | 0.72 | KDM4E (0.37) | HTTALDH1A1MAPTSMN1; SMN2HPGD | |
| Lithium Ion SCHEMBL25346138 | 0.72 | KDM4E (0.37) | MAPTMEN1KMT2APHGDH | |
| SCHEMBL7592068 | 0.70 | HTT (0.70) | HTTALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL22290279 | 0.70 | CA12 (0.45) | ALDH1A1L3MBTL1MAPTSMN1; SMN2HPGD | |
| SCHEMBL20519426 | 0.70 | BAZ2B (0.47) | ALDH1A1L3MBTL1MAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231474-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |