Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676612 | 0.79 | KDM4E (0.45) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL20799425 | 0.78 | MAOB (0.44) | KDM4EHSD17B10NPC1RAB9AMAOB | |
| SCHEMBL16595609 | 0.74 | FLT3 (0.49) | KDM4EFLT3TYRDAOAKR1B1 | |
| SCHEMBL2424372 | 0.73 | CYP2D6 (0.45) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL8036000 | 0.72 | KDM4E (0.46) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL28750544 | 0.71 | MAPT (0.45) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL800706 | 0.71 | KDM4E (0.44) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL28018770 | 0.70 | KDM4E (0.44) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL23692162 | 0.68 | MAOB (0.43) | KDM4EFLT3MGLLHSD17B10TDP1 | |
| SCHEMBL5776749 | 0.68 | FLT3 (0.46) | KDM4EFLT3MGLLHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912977-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2021-11-24 | — | — | EP | disclosed |