Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF1 | Q13422 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 17/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24132551 | 0.85 | CRBN (0.39) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL29367303 | 0.82 | CRBN (0.42) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL22291652 | 0.82 | CRBN (0.42) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL23594483 | 0.79 | CRBN (0.43) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL22291602 | 0.79 | DDB1 (0.54) | IKZF1CRBNDDB1IKZF2 | |
| SCHEMBL23986383 | 0.78 | CRBN (0.46) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL22006673 | 0.78 | CRBN (0.46) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL25469933 | 0.78 | CRBN (0.46) | IKZF1CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL25097038 | 0.77 | CRBN (0.47) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL20233810 | 0.77 | CRBN (0.62) | IKZF1CRBNDDB1IKZF3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210363146-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2021-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363146-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | MUSK, NTRK1, ERBB2 | IKZF1 1556/4885CRBN 194/4885DDB1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.