Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 1.00 |
| ▸ | INSR | P06213 | 2/20 | 0.84 |
| ▸ | LCK | P06239 | 2/20 | 0.84 |
| ▸ | LTK | P29376 | 2/20 | 0.84 |
| ▸ | AXL | P30530 | 2/20 | 0.84 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.84 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.84 |
| ▸ | MERTK | Q12866 | 2/20 | 0.84 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.84 |
| ▸ | FLT3 | P36888 | 1/20 | 0.84 |
| ▸ | SPR | P35270 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21759921 | 1.00 | ALK (1.00) | ALKINSRLCKLTKAXL | |
| SCHEMBL21135589 | 0.94 | ALK (0.88) | ALKINSRLCKLTKAXL | |
| SCHEMBL23915691 | 0.94 | ALK (0.88) | ALKINSRLCKLTKAXL | |
| SCHEMBL10270586 | 0.92 | ALK (0.85) | ALKINSRLCKLTKAXL | |
| SCHEMBL573407 | 0.92 | ALK (1.00) | ALKINSRLCKLTKAXL | |
| SCHEMBL573406 | 0.92 | ALK (1.00) | ALKINSRLCKLTKAXL | |
| SCHEMBL23810096 | 0.92 | ALK (0.90) | ALKINSRLCKLTKAXL | |
| SCHEMBL23810121 | 0.92 | ALK (0.90) | ALKINSRLCKLTKAXL | |
| SCHEMBL21206279 | 0.91 | ALK (1.00) | ALKINSRLCKLTKAXL | |
| SCHEMBL24046243 | 0.91 | ALK (1.00) | ALKINSRLCKLTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257380-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2023-08-17 | — | — | US | disclosed |
| US-20210363146-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2021-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257380-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | MUSK, ERBB2, NTRK1 | ALK 140/4885INSR 2131/4885LCK 88/4885 |
| US-20210363146-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | MUSK, NTRK1, ERBB2 | ALK 237/4885INSR 1996/4885LCK 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.