Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.46 |
| ▸ | MRE11 | P49959 | 1/20 | 0.46 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23714619 | 0.92 | MRE11 (0.46) | ABL1ROCK1ROCK2MRE11GPR142 | |
| SCHEMBL21225217 | 0.88 | HDAC6 (0.49) | ABL1ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL21225216 | 0.88 | HDAC6 (0.49) | ABL1ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL30657979 | 0.88 | HDAC6 (0.49) | ABL1ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL21241867 | 0.88 | PARP1 (0.53) | ROCK1MRE11GPR142PARP1 | |
| Hydrochloric Acid SCHEMBL23851366 | 0.87 | HDAC6 (0.48) | ABL1ROCK1ROCK2MRE11PARP1 | |
| Hydrochloric Acid SCHEMBL30319901 | 0.87 | HDAC6 (0.48) | ABL1ROCK1ROCK2MRE11PARP1 | |
| Hydrochloric Acid SCHEMBL23851364 | 0.87 | HDAC6 (0.48) | ABL1ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL21225301 | 0.86 | HDAC4 (0.47) | ROCK1ROCK2MRE11PRKACAHDAC4 | |
| SCHEMBL21225303 | 0.86 | HDAC4 (0.47) | ROCK1ROCK2MRE11PRKACAHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236080-A1 | METHODS OF TREATING CANCERS | FOGHORN THERAPEUTICS INC. (US) | 2021-11-25 | — | — | WO | disclosed |