Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.48 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | MRE11 | P49959 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241805 | 1.00 | SMARCA2 (0.48) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL23715360 | 0.88 | SMARCA2 (0.49) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL21225225 | 0.86 | SMARCA2 (0.65) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL21225224 | 0.86 | SMARCA2 (0.65) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL21241867 | 0.85 | PARP1 (0.53) | MEN1KMT2APARP1ALDH1A1MAPT | |
| SCHEMBL21224191 | 0.83 | PARP1 (0.46) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL22971637 | 0.83 | PARP1 (0.46) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL21224192 | 0.83 | PARP1 (0.46) | SMARCA2SMARCA4MEN1KMT2APARP1 | |
| SCHEMBL24049451 | 0.81 | ABL1 (0.47) | PARP1CYP3A4HDAC4MEF2DEP300 | |
| SCHEMBL23714619 | 0.81 | MRE11 (0.46) | PARP1CYP3A4HDAC4MEF2DEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236080-A1 | METHODS OF TREATING CANCERS | FOGHORN THERAPEUTICS INC. (US) | 2021-11-25 | — | — | WO | disclosed |