Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PMM2 | O15305 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16236935 | 0.84 | MAOB (0.55) | MAOBKMT2ABRD4LMNAALDH1A1 | |
| SCHEMBL5434666 | 0.81 | ELANE (0.55) | KMT2ALMNAALDH1A1CNR1NPC1 | |
| SCHEMBL5438329 | 0.80 | ELANE (0.59) | KMT2ALMNAALDH1A1MEN1TP53 | |
| SCHEMBL5438359 | 0.80 | ELANE (0.54) | LMNAHPGD | |
| SCHEMBL5441836 | 0.80 | ELANE (0.54) | KMT2ALMNAALDH1A1HPGDGAA | |
| SCHEMBL5445075 | 0.80 | ELANE (0.52) | — | |
| SCHEMBL5434795 | 0.80 | MAPK14 (0.55) | TP53 | |
| SCHEMBL5757403 | 0.80 | CNR1 (0.64) | KMT2ABRD4ALDH1A1CNR1CNR2 | |
| SCHEMBL5440472 | 0.79 | DDT (0.56) | LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5438601 | 0.79 | LMNA (0.55) | KMT2ALMNAHPGDGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021237112-A1 | NOTCH INHIBITORS AND USES THEREOF | STEMSYNERGY THERAPEUTICS, INC. (US) | 2021-11-25 | — | — | WO | disclosed |