Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | BRS3 | P32247 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323790 | 0.85 | KDM4E (0.50) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2406990 | 0.82 | MAPT (0.47) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2405487 | 0.81 | MKNK1 (0.49) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2406561 | 0.81 | MAPT (0.46) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL287699 | 0.80 | KDM4E (0.57) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL3389125 | 0.80 | KDM4E (0.49) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2559502 | 0.79 | MAPT (0.50) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2404881 | 0.78 | KDM4E (0.44) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL5258713 | 0.78 | KDM4E (0.50) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL21050082 | 0.78 | NPC1 (0.55) | KDM4EALDH1A1TSHRMYCBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | KDM4E 452/4885MAPT 1419/4885ALDH1A1 2292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.