Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.65 |
| ▸ | KCNMA1 | Q12791 | 9/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24063504 | 0.89 | PDE9A (0.53) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL24063436 | 0.88 | PDE9A (0.51) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL24276341 | 0.88 | PDE9A (0.50) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL22298182 | 0.76 | KDM5A (0.56) | PDE9APDE1CPARP1DHODH | |
| SCHEMBL24276323 | 0.75 | PDE9A (0.51) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL20870085 | 0.72 | KCNMA1 (0.63) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL4754780 | 0.72 | PDE9A (0.60) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL22224785 | 0.72 | PDE9A (0.49) | PDE9APDE1CKDM4E | |
| SCHEMBL22275015 | 0.72 | PDE9A (0.48) | PDE9AKCNMA1PARP1KDM4E | |
| SCHEMBL24276304 | 0.71 | PDE9A (0.50) | PDE9AKCNMA1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915992-A1 | PDE9 INHIBITOR AND USE THEREOF | Transthera Sciences (Nanjing), Inc. (CN) | 2021-12-01 | — | — | EP | disclosed |