Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12318251 | 0.83 | PDE4D (0.58) | PDE4BPDE4APDE4CPDE4DCHEK2 | |
| SCHEMBL1936992 | 0.83 | SCD (0.41) | — | |
| SCHEMBL2408739 | 0.82 | POLB (0.46) | OPRK1 | |
| SCHEMBL2444039 | 0.80 | PDE4D (0.52) | PDE4BPDE4APDE4CPDE4DCHEK2 | |
| SCHEMBL27900126 | 0.79 | PARP10 (0.67) | OPRK1CHEK2PARP10KCNH2 | |
| SCHEMBL27900111 | 0.77 | OPRK1 (0.68) | OPRK1OPRM1KCNH2 | |
| SCHEMBL23195608 | 0.77 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL30138074 | 0.77 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3794283 | 0.77 | PDE4B (0.43) | OPRK1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL19030310 | 0.76 | IKBKB (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539344-A1 | HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104338-A1 | HALOGEN OR CYANO SUBSTITUTED THIENO [2,3-D]PYRIMIDINES HAVING MNK1/MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-01 | — | — | WO | disclosed |