Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbamoylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 8/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 7/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 7/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 6/20 | 1.00 |
| ▸ | CHRNB2 | P17787 | 4/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 4/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.62 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamoylcholine SCHEMBL2792 | 1.00 | CHRM1 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL3917468 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL2063604 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL16320707 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL5060882 | 0.98 | CHRM5 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL27766145 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL2791 | 0.98 | CHRM5 (1.00) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL4727962 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL21067459 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Carbamoylcholine SCHEMBL9792919 | 0.98 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212090-A1 | Combinatorial Analysis and Repair | DAKO DENMARK A/S | 2011-09-01 | — | — | US | disclosed |
| EP-1931760-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | The University of Alabama (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044693-A2 | MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS | THE UNIVERSITY OF ALABAMA (US) | 2007-04-19 | — | — | WO | disclosed |
| US-6101412-A | Compositions, apparatus and methods for facilitating surgical procedures | DUKE UNIVERSITY (US) | 2000-08-08 | — | — | US | disclosed |
| US-6087394-A | DELIVERING AN ATRIOVENTRICULAR NODE BLOCKER TO THE ATRIOVENTRICULAR NODE OF THE PATIENT VIA THE CORONARY VESSEL AND INDUCING TRANSIENT REVERSIBLE VENTRICULAR ASYSTOLE IN THE HEART; USING IN CARDIAC, VASCULAR, NEUROSURGICAL PROCEDURES | DUKE UNIVERSITY (US) | 2000-07-11 | — | — | US | disclosed |
| US-6060454-A | ADMINISTERING BETA-BLOCKER AND ATRIOVENTRICULAR NODE BLOCKER TO INDUCE REVERSIBLE VENTRICULAR ASYSTOLE | DUKE UNIVERSITY (US) | 2000-05-09 | — | — | US | disclosed |
| US-6043273-A | COMPOSITION COMPRISING COMPOUND CAPABLE OF INDUCING TRANSIENT REVERSIBLE VENTRICULAR ASYSTOLE AND BETA-BLOCKER TO REDUCE AMOUNT OF SAID COMPOUND REQUIRED | DUKE UNIVERSITY (US) | 2000-03-28 | — | — | US | disclosed |