Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.36 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25730278 | 0.88 | TYK2 (0.37) | CHEK1MAPKAPK2FLT3IRAK1IRAK4 | |
| SCHEMBL25730279 | 0.86 | TYK2 (0.33) | CHEK1MAPKAPK2IRAK4LCKTYK2 | |
| SCHEMBL24068103 | 0.78 | CNR1 (0.47) | JAK1CCNT1ALDH1A1 | |
| SCHEMBL25235366 | 0.73 | CCR2 (0.34) | — | |
| SCHEMBL24068172 | 0.72 | KDM4E (0.32) | ALDH1A1CYP3A4 | |
| SCHEMBL24068059 | 0.64 | MAPK1 (0.43) | CHEK1FLT3IRAK4TYK2JAK2 | |
| SCHEMBL31619957 | 0.60 | MAPK1 (0.64) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL25730233 | 0.60 | — | — | |
| SCHEMBL5774301 | 0.60 | CYP1A2 (0.41) | FLT3IRAK1IRAK4LCKRET | |
| SCHEMBL18829880 | 0.60 | DDR1 (0.43) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667257-B | Compounds for inhibiting CDK7 | 伊莱利利公司 | 2024-06-11 | — | — | CN | disclosed |
| US-20230203031-A1 | COMPOUNDS USEFUL FOR INHIBITING CDK7 | ELI LILLY AND COMPANY | 2023-06-29 | — | — | US | disclosed |
| US-20230203031-A1 | COMPOUNDS USEFUL FOR INHIBITING CDK7 | ELI LILLY AND COMPANY | 2023-06-29 | — | — | US | disclosed |
| EP-4157840-A1 | COMPOUNDS USEFUL FOR INHIBITING CDK7 | Eli Lilly and Company (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115667257-A | Compounds for inhibiting CDK7 | 伊莱利利公司 | 2023-01-31 | — | — | CN | disclosed |
| WO-2021242602-A1 | COMPOUNDS USEFUL FOR INHIBITING CDK7 | ELI LILLY AND COMPANY (US) | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203031-A1 | COMPOUNDS USEFUL FOR INHIBITING CDK7 | CDK7, CDK3, CCNH | CHEK1 100/4885MAPKAPK2 337/4885FLT3 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.