Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792293 | 0.80 | ELANE (0.46) | ELANESCN9AKMT2ASMN1; SMN2LMNA | |
| SCHEMBL2221010 | 0.73 | ELANE (0.49) | ELANEKMT2ABRD4EPHX2HPGD | |
| SCHEMBL4059205 | 0.73 | ELANE (0.49) | ELANEKMT2ASMN1; SMN2BRD4HPGD | |
| SCHEMBL7913179 | 0.72 | ELANE (0.40) | ELANEKMT2ASMN1; SMN2BRD4EPHX2 | |
| SCHEMBL411674 | 0.72 | ELANE (0.40) | ELANEMTNR1AMTNR1BBRD4CA2 | |
| SCHEMBL7714404 | 0.72 | ELANE (0.41) | ELANESCN9AKMT2AMTNR1AMTNR1B | |
| SCHEMBL7711834 | 0.71 | ELANE (0.39) | ELANEKMT2ABRD4ATMCA2 | |
| SCHEMBL14839466 | 0.71 | ELANE (0.44) | ELANEKMT2AMTNR1AMTNR1BBRD4 | |
| SCHEMBL7882101 | 0.70 | ELANE (0.38) | ELANEKMT2ABRD4ATMCA2 | |
| SCHEMBL16958507 | 0.69 | ELANE (0.37) | ELANEBRD4EPHX2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021239058-A1 | FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2021-12-02 | — | — | WO | disclosed |