Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30369632 | 1.00 | ALDH1A1 (0.47) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL24069920 | 0.83 | ALDH1A1 (0.45) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL15162220 | 0.82 | HTT (0.53) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL15162764 | 0.82 | HTT (0.53) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL24069085 | 0.78 | POLB (0.48) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL30209728 | 0.78 | POLB (0.48) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL30209757 | 0.78 | POLB (0.48) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL24069136 | 0.78 | POLB (0.48) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL30209754 | 0.78 | POLB (0.48) | ALDH1A1HTTLMNAPOLBGAA | |
| SCHEMBL15162426 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HTTLMNAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867535-A | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2021243001-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |