Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 5/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | GFER | P55789 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22609135 | 0.78 | KIT (0.36) | ALDH1A1KITDDR1BRAFMAPK1 | |
| SCHEMBL8448727 | 0.74 | KIT (0.36) | KITDDR1MAPTBRAFL3MBTL1 | |
| SCHEMBL25124396 | 0.70 | BRAF (0.42) | KITDDR1BRAFKDM4E | |
| SCHEMBL22109091 | 0.69 | DGAT1 (0.35) | KITDDR1LMNABRAFMAPK1 | |
| SCHEMBL25702690 | 0.68 | PDE4B (0.35) | KITDDR1BRAF | |
| SCHEMBL25251073 | 0.68 | LRRK2 (0.43) | ALDH1A1MAPTLMNAMAPK1L3MBTL1 | |
| SCHEMBL10983164 | 0.67 | SMN1; SMN2 (0.40) | MAPTLMNAMAPK1L3MBTL1TDP1 | |
| SCHEMBL23545919 | 0.67 | KIT (0.36) | KITDDR1BRAF | |
| SCHEMBL16478046 | 0.67 | DGAT1 (0.37) | ALDH1A1KITDDR1MAPTL3MBTL1 | |
| SCHEMBL15019947 | 0.67 | KIT (0.37) | KITDDR1BRAFNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021239643-A1 | BENZYLAMINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-12-02 | — | — | WO | disclosed |