Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14643108 | 0.85 | ADK (0.42) | SRCLCKFLT3TEKADK | |
| SCHEMBL16236628 | 0.84 | FLT3 (0.53) | SRCLCKFLT3TEKNSD3 | |
| SCHEMBL29999160 | 0.84 | FLT3 (0.53) | SRCLCKFLT3TEKNSD3 | |
| SCHEMBL24072614 | 0.83 | SRC (0.54) | SRCLCKFLT3TEKADK | |
| SCHEMBL20351726 | 0.82 | ADK (0.40) | FLT3LMNASMN1; SMN2HPGDADK | |
| SCHEMBL10262517 | 0.79 | SRC (0.44) | SRCLCKFLT3TEKADK | |
| SCHEMBL14643788 | 0.79 | SRC (0.47) | SRCLCKFLT3TEKADK | |
| SCHEMBL20351588 | 0.79 | SRC (0.57) | SRCLCKFLT3TEK | |
| SCHEMBL26831072 | 0.76 | RPS6KB1 (0.47) | SRCFLT3ADKADORA2AADORA1 | |
| SCHEMBL10261380 | 0.75 | FLT3 (0.47) | SRCLCKFLT3TEKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021242505-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-02 | — | — | WO | disclosed |