Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.69 |
| ▸ | MET | P08581 | 15/20 | 0.60 |
| ▸ | INSR | P06213 | 6/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24073050 | 0.90 | AXL (0.64) | AXLMETINSRALKMAPK9 | |
| SCHEMBL25834866 | 0.90 | AXL (0.64) | AXLMETINSRALKMAPK9 | |
| SCHEMBL24073799 | 0.87 | MET (0.71) | METINSRALKMAPK9MAPK10 | |
| SCHEMBL24073484 | 0.85 | MET (0.73) | METINSRALKMAPK9MAPK10 | |
| SCHEMBL12964728 | 0.82 | AXL (1.00) | AXLALKEGFRAURKA | |
| SCHEMBL24073734 | 0.80 | MAPK9 (0.66) | AXLMETINSRALKMAPK9 | |
| SCHEMBL24073798 | 0.80 | MAPK9 (0.66) | AXLMETINSRALKMAPK9 | |
| SCHEMBL24073946 | 0.80 | MET (0.69) | AXLMETINSRALKEGFR | |
| SCHEMBL886740 | 0.80 | MET (0.83) | METINSRALKMAPK9MAPK10 | |
| SCHEMBL885475 | 0.79 | MET (0.78) | METINSRALKMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021239133-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | 南京正大天晴制药有限公司 | 2021-12-02 | — | — | WO | disclosed |