Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.58 |
| ▸ | ITGB6 | P18564 | 16/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.58 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL275852 | 0.97 | ITGAV (0.55) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL2233629 | 0.93 | ITGAV (0.67) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL2233619 | 0.93 | ITGAV (0.67) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL274823 | 0.93 | ITGAV (0.52) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328050 | 0.90 | ITGAV (0.65) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328085 | 0.89 | ITGAV (0.66) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328042 | 0.88 | ITGAV (0.64) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL12459429 | 0.87 | ITGB3 (0.60) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL2955533 | 0.86 | ITGAV (0.60) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL278708 | 0.86 | ITGAV (0.60) | ITGAVITGB6ITGB3ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747222-B1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | GALAPAGOS NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| EP-2368891-B1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | GALAPAGOS NV (BE) | 2012-09-19 | — | — | EP | disclosed |
| EP-2368891-A1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | Galapagos SAS (FR) | 2011-09-28 | — | — | EP | disclosed |
| US-7825119-B2 | Bone disorders such as osteoporosis, tumors and cardiovascular disorders; 4-(2-carboxy-2-Boc-aminoethylamino)-6-piperidinopyrimidines such as tert-butyl 2-benzyloxycarbonylamino-3-[2,5-dimethoxy-6-(4-[1,8]naphthyridin-2-yl-piperidin-1-yl)pyrimidin-4-ylamino]-propionate | GALAPAGOS SAS (FR) | 2010-11-02 | — | — | US | disclosed |