Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.59 |
| ▸ | P2RY1 | P47900 | 8/20 | 0.51 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.49 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121327 | 0.84 | ADORA3 (0.67) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL12269667 | 0.83 | ADORA3 (0.66) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL10121165 | 0.77 | ADORA3 (0.74) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL5816714 | 0.75 | ADORA3 (0.82) | ADORA3ADORA1P2RY1HSP90B1TMIGD3 | |
| SCHEMBL5816711 | 0.75 | ADORA3 (0.82) | ADORA3ADORA1P2RY1HSP90B1TMIGD3 | |
| SCHEMBL12269798 | 0.73 | P2RY1 (0.58) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL10121164 | 0.73 | P2RY1 (0.73) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL10121166 | 0.73 | P2RY1 (0.73) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL12269658 | 0.73 | ADORA3 (0.77) | ADORA3ADORA1P2RY1HSP90B1P2RY2 | |
| SCHEMBL17830413 | 0.72 | P2RY1 (0.72) | ADORA3ADORA1P2RY1HSP90B1P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539352-B1 | AMP DERIVATIVES FOR TREATING CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2017-10-04 | — | — | EP | disclosed |
| US-9526739-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | GOOGLE LLC | 2016-06-16 | — | — | US | disclosed |
| US-9303053-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2015-02-05 | — | — | US | disclosed |
| US-8822434-B2 | Compositions and methods to treat cardiac diseases | THE UNIVERSITY OF CONNECTICUT (US) | 2014-09-02 | — | — | US | disclosed |
| WO-2011103552-A9 | AMP DERIVATIVES FOR TREATING CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2012-04-26 | — | — | WO | disclosed |
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | ADORA3 84/4885ADORA1 29/4885P2RY1 4/4885 |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | ADORA3 84/4885ADORA1 29/4885P2RY1 4/4885 |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | ADORA3 84/4885ADORA1 29/4885P2RY1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.