SCHEMBL24075827

SCHEMBL24075827

CC1NS(=O)Oc2c(-c3ccc(Oc4ccccc4)cc3)cccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.39
PTGS2 P35354 1/20 0.36
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
FFAR1 O14842 2/20 0.33
FFAR4 Q5NUL3 1/20 0.33
LTA4H P09960 2/20 0.33
TLR8 Q9NR97 1/20 0.33
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
BRD4 O60885 1/20 0.32
NCOA1 Q15788 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
ALOX12 P18054 1/20 0.31
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
SCN9A Q15858 1/20 0.31
HTR1A P08908 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24074881 0.89 HTR2B (0.36) PTGS2BRD4HTR1AHTR7HTR2B
SCHEMBL24075519 0.88 CYP3A4 (0.39) CYP3A4CYP2C9HTR1AHTR7MEN1
SCHEMBL24075598 0.86 CYP3A4 (0.38) CYP3A4CYP2C9MEN1KMT2A
SCHEMBL24075599 0.85 BRD4 (0.45) GSTP1BRD4MEN1KMT2A
SCHEMBL24075521 0.84 HCRTR1 (0.39) FFAR1FFAR4ALDH1A1SCN9AMEN1
SCHEMBL24074898 0.84 BRD4 (0.42) BRD4ALDH1A1HTTMEN1KMT2A
SCHEMBL24075601 0.84 GRM2 (0.40) LMNAMEN1KMT2ACYP19A1
SCHEMBL24075600 0.83 EDNRB (0.32) ALDH1A1MEN1KMT2A
SCHEMBL24075819 0.82 EDNRB (0.34) MEN1KMT2A
SCHEMBL24075665 0.82 PTGS2 (0.34) PTGS2ALDH1A1HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021238588-A1 OXATHIAZINE COMPOUND AND USE THEREOF 四川大学华西医院 2021-12-02 WO disclosed