Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19349269 | 0.90 | BRAF (0.46) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL19349471 | 0.88 | RET (0.40) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL19349446 | 0.86 | RET (0.43) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL19349332 | 0.86 | NPC1 (0.42) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL19349306 | 0.86 | BRAF (0.43) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL19349542 | 0.85 | RET (0.48) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL19349405 | 0.83 | BRAF (0.45) | BRAFNPC1LMNAPKMCDK8 | |
| SCHEMBL19349307 | 0.83 | RET (0.39) | BRAFRETNPC1LMNAPKM | |
| SCHEMBL24081778 | 0.80 | BRAF (0.43) | BRAF | |
| SCHEMBL24081691 | 0.78 | NPC1 (0.39) | BRAFRETNPC1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3430005-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION AND INDICATIONS THEREFORE | PLEXXIKON INC (US) | 2021-12-08 | — | — | EP | disclosed |