Sugi Predict

Sugi Predict / Compounds / SCHEMBL2408370

SCHEMBL2408370

SCHEMBL2408370

CC(C)C(NC(=O)c1cc(C(F)(F)F)ccc1C(F)(F)F)c1ccc(C(=O)NO)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 3/20 0.54
▸ PDE2A O00408 6/20 0.47
▸ CES2 O00748 1/20 0.46
▸ PSMB11 A5LHX3 6/20 0.45
▸ PSMA7 O14818 6/20 0.45
▸ PSMB1 P20618 6/20 0.45
▸ PSMA1 P25786 6/20 0.45
▸ PSMA2 P25787 6/20 0.45
▸ PSMA3 P25788 6/20 0.45
▸ PSMA4 P25789 6/20 0.45
▸ PSMB8 P28062 6/20 0.45
▸ PSMB9 P28065 6/20 0.45
▸ PSMA5 P28066 6/20 0.45
▸ PSMB4 P28070 6/20 0.45
▸ PSMB6 P28072 6/20 0.45
▸ PSMB5 P28074 6/20 0.45
▸ PSMB10 P40306 6/20 0.45
▸ PSMB3 P49720 6/20 0.45
▸ PSMB2 P49721 6/20 0.45
▸ PSMA6 P60900 6/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12279611 0.88 HDAC1 (0.54) HDAC1PDE2AHDAC8HDAC6
SCHEMBL2408922 0.83 HDAC1 (0.63) HDAC1PDE2AHDAC8HDAC6
SCHEMBL12279645 0.79 HDAC1 (0.57) HDAC1PDE2AHDAC8HDAC6
SCHEMBL13753420 0.79 CES2 (0.57) CES2PSMB11PSMA7PSMB1PSMA1
SCHEMBL13753370 0.78 CES2 (0.60) CES2PSMB11PSMA7PSMB1PSMA1
SCHEMBL2407612 0.77 HDAC1 (0.60) HDAC1PDE2AHDAC8HDAC6
SCHEMBL2406113 0.76 HDAC1 (0.50) HDAC1PDE2AHDAC8HDAC6
SCHEMBL2405287 0.76 HDAC1 (0.71) HDAC1HDAC8HDAC6
SCHEMBL2408319 0.76 HDAC6 (0.53) HDAC1PDE2AHDAC8HDAC6
SCHEMBL2408207 0.74 HDAC1 (0.73) HDAC1HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9382197-B2 Substituted hydroxamic acids and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2016-07-05 — — US disclosed
US-9382197-B2 Substituted hydroxamic acids and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2016-07-05 — — US disclosed
US-20140275093-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2014-09-18 — — US disclosed
US-20140275093-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2014-09-18 — — US disclosed
WO-2011106632-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-09-01 — — WO disclosed
US-20110212969-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-09-01 — — US disclosed
US-20110212969-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-09-01 — — US disclosed
WO-2011106632-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-09-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140275093-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF HDAC6, HDAC10, HDAC1 HDAC1 3/4885PDE2A 3053/4885CES2 2061/4885
US-20110212969-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF HDAC6, HDAC10, HDAC1 HDAC1 3/4885PDE2A 3053/4885CES2 2061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.