Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.88 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.63 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476536 | 0.99 | S1PR1 (0.86) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL1602860 | 0.94 | S1PR1 (1.00) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL1602305 | 0.93 | S1PR1 (0.98) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL1603424 | 0.85 | S1PR1 (0.83) | S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL1600910 | 0.83 | S1PR1 (0.79) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL16152955 | 0.82 | S1PR1 (0.81) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL2416672 | 0.82 | S1PR1 (0.73) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL1602550 | 0.82 | S1PR1 (1.00) | S1PR1S1PR3KCNH2 | |
| SCHEMBL1602756 | 0.81 | S1PR1 (1.00) | S1PR1S1PR3S1PR5S1PR4KCNH2 | |
| SCHEMBL12269296 | 0.81 | S1PR1 (0.78) | S1PR1S1PR3S1PR5S1PR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364976-B1 | S1P receptor modulating compounds and use thereof | EPIX PHARM INC (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-2364976-A1 | S1P receptor modulating compounds and use thereof | EPIX Pharmaceuticals, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |