Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.75 |
| ▸ | AR | P10275 | 7/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1560703 | 0.89 | ESR1 (0.78) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10433065 | 0.87 | LCK (0.67) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432596 | 0.86 | ESR1 (1.00) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432799 | 0.86 | ESR1 (0.74) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432664 | 0.84 | ESR1 (0.76) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432657 | 0.83 | ESR1 (0.61) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432916 | 0.83 | ESR1 (0.78) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432638 | 0.82 | ESR1 (0.68) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432584 | 0.82 | ESR1 (0.68) | ESR1ESR2ARCYP3A4MAPT | |
| SCHEMBL10432678 | 0.82 | AR (0.71) | ESR1ESR2ARCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755928-B1 | 5-AMINOFLAVONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-04-10 | — | — | EP | claimed |
| EP-0638566-B1 | 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent | KYOWA HAKKO KOGYO KK (JP) | 1999-01-07 | — | — | EP | claimed |
| EP-0755928-A1 | 5-AMINOFLAVONE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-01-29 | — | — | EP | claimed |
| US-5539112-A | 5-aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-23 | — | — | US | claimed |
| EP-0638566-A1 | 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-02-15 | — | — | EP | claimed |
| JP-7109268-A | — | — | None | — | — | JP | disclosed |
| US-20130177904-A1 | ARNT ISOFORM 3 AS A PREDICTOR OF AMINOFLAVONE RESPONSIVENESS IN CANCER CELLS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-07-11 | — | — | US | disclosed |
| WO-2011106373-A2 | ARNT ISOFORM 3 AS A PREDICTOR OF AMINOFLAVONE RESPONSIVENESS IN CANCER CELLS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2011-09-01 | — | — | WO | disclosed |
| EP-1373243-B1 | AMINOFLAVONE COMPOUNDS, COMPOSITIONS, AND USE THEREOF | US GOV HEALTH & HUMAN SERV (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040019227-A1 | Aminoflavone compounds, compositions, and methods of use | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-1373243-A1 | AMINOFLAVONE COMPOUNDS, COMPOSITIONS, AND USE THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081462-A1 | AMINOFLAVONE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-10-17 | — | — | WO | disclosed |
| EP-0638566-A1 | 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| EP-0638566-A1 | 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| EP-0556720-A1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |
| EP-0556720-A1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |
| EP-0556720-A1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |
| EP-0374789-A1 | 5- Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-06-27 | — | — | EP | disclosed |
| EP-0374789-A1 | 5- Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-06-27 | — | — | EP | disclosed |
| EP-0374789-A1 | 5- Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019227-A1 | Aminoflavone compounds, compositions, and methods of use | HDGF, ERBB2, ING2 | ESR1 2547/4885ESR2 299/4885AR 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.