Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MYOC | Q99972 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24091750 | 0.85 | HSPB1 (0.51) | HSPB1ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL21166650 | 0.79 | MAPT (0.57) | ALDH1A1POLBMAPK1CYP3A4TSHR | |
| SCHEMBL15055286 | 0.77 | NPC1 (0.58) | HSPB1ALDH1A1POLBPTGS2MAPK1 | |
| SCHEMBL23228769 | 0.76 | PARP10 (0.51) | ALDH1A1POLBTSHRKMT2ARAB9A | |
| SCHEMBL21656483 | 0.75 | MAPT (0.44) | ALDH1A1MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL21656587 | 0.75 | HPGD (0.58) | ALDH1A1POLBTSHRMAPTRAB9A | |
| SCHEMBL21656579 | 0.75 | CA1 (0.45) | POLBTSHRMAPTRAB9ANPC1 | |
| SCHEMBL23228794 | 0.74 | HPGD (0.56) | ALDH1A1POLBTSHRKMT2AMEN1 | |
| SCHEMBL9082994 | 0.73 | HSPB1 (0.59) | HSPB1ALDH1A1MAPK1CYP3A4TSHR | |
| SCHEMBL15279922 | 0.73 | HSPB1 (0.59) | HSPB1ALDH1A1POLBPTGS2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210382038-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210382038-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | NOTCH3, NOTCH1, NOTCH4 | HSPB1 4691/4885ALDH1A1 3224/4885POLB 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.