Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054998 | 0.85 | KDM4E (0.71) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL31247993 | 0.85 | KDM4E (0.71) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL21166757 | 0.84 | KDM4E (0.61) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL31225411 | 0.83 | KDM4E (0.73) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL15055437 | 0.83 | KDM4E (0.73) | KDM4ERAB9APOLBMEN1KMT2A | |
| Limantrafin SCHEMBL4638726 | 0.80 | KDM4E (1.00) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL28055507 | 0.80 | KDM4E (0.82) | KDM4ERAB9APOLBMEN1KMT2A | |
| Limantrafin SCHEMBL25340427 | 0.80 | KDM4E (1.00) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL30601045 | 0.80 | KDM4E (0.82) | KDM4ERAB9APOLBMEN1KMT2A | |
| SCHEMBL28064235 | 0.80 | KDM4E (0.82) | KDM4ERAB9APOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210382038-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210382038-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | NOTCH3, NOTCH1, NOTCH4 | KDM4E 338/4885RAB9A 3388/4885POLB 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.