Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24610278 | 0.83 | RET (0.48) | IGF1RRETKDM4EAPAF1ALDH1A1 | |
| SCHEMBL22281362 | 0.80 | ROCK2 (0.45) | IGF1RSYKMAOBEGFRMEN1 | |
| SCHEMBL5334189 | 0.80 | FLT1 (0.52) | IGF1RRETKDM4EAPAF1ALDH1A1 | |
| SCHEMBL5336694 | 0.76 | FLT1 (0.52) | IGF1RRETKDM4EAPAF1ALDH1A1 | |
| SCHEMBL22281026 | 0.75 | ROCK2 (0.52) | TNIKKDRNPC1ROCK2ROCK1 | |
| SCHEMBL5333896 | 0.74 | KDR (0.44) | IGF1RRETKDM4EAPAF1ALDH1A1 | |
| SCHEMBL22966949 | 0.73 | MAOB (0.46) | RETTNIKSYKMAOBEGFR | |
| SCHEMBL22966899 | 0.73 | RET (0.51) | IGF1RRETTNIKKDRSYK | |
| SCHEMBL24094235 | 0.72 | NPC1 (0.44) | RETKDM4EAPAF1ALDH1A1MAPT | |
| SCHEMBL22281024 | 0.72 | ROCK2 (0.48) | TNIKNPC1ROCK2ROCK1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |