Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407846 | 0.88 | PDE2A (0.54) | HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL12279807 | 0.88 | HDAC6 (0.61) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL2413458 | 0.84 | HDAC1 (0.56) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL12280148 | 0.84 | HDAC1 (0.56) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL2408485 | 0.84 | CA1 (0.64) | HDAC1HDAC6HDAC8ALDH1A1SMN1; SMN2 | |
| SCHEMBL2406733 | 0.84 | HDAC8 (0.58) | HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL2405287 | 0.84 | HDAC1 (0.71) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL2410420 | 0.83 | NR1H4 (0.78) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL12280557 | 0.83 | HDAC6 (0.54) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL2409455 | 0.83 | HDAC1 (0.48) | HDAC1HDAC6HDAC8HDAC3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | claimed |
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC10, HDAC1 | HDAC1 3/4885HDAC6 1/4885HDAC8 15/4885 |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC10, HDAC1 | HDAC1 3/4885HDAC6 1/4885HDAC8 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.