Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.58 |
| ▸ | PDE2A | O00408 | 8/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12279574 | 0.93 | HDAC8 (0.50) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL2407846 | 0.92 | PDE2A (0.54) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL2408922 | 0.85 | HDAC1 (0.63) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL2409455 | 0.84 | HDAC1 (0.48) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL2409463 | 0.84 | HDAC1 (0.67) | HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL12279807 | 0.81 | HDAC6 (0.61) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL12279645 | 0.78 | HDAC1 (0.57) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL2407905 | 0.78 | LMNA (0.57) | HDAC8HDAC6PDE2AHDAC1 | |
| SCHEMBL2413458 | 0.77 | HDAC1 (0.56) | HDAC8HDAC6HDAC3PDE2AHDAC1 | |
| SCHEMBL12280148 | 0.77 | HDAC1 (0.56) | HDAC8HDAC6HDAC3PDE2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | claimed |
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC10, HDAC1 | HDAC8 15/4885HDAC6 1/4885HDAC3 5/4885 |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC10, HDAC1 | HDAC8 15/4885HDAC6 1/4885HDAC3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.