Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22159680 | 0.92 | APOL1 (0.81) | APOL1 | |
| SCHEMBL22161107 | 0.92 | APOL1 (0.76) | APOL1 | |
| SCHEMBL30218287 | 0.92 | APOL1 (0.76) | APOL1 | |
| SCHEMBL22160171 | 0.90 | APOL1 (0.76) | APOL1 | |
| SCHEMBL22160169 | 0.90 | APOL1 (0.76) | APOL1 | |
| SCHEMBL22160349 | 0.88 | APOL1 (0.87) | APOL1 | |
| SCHEMBL22160167 | 0.86 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22118479 | 0.86 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22118344 | 0.86 | APOL1 (1.00) | APOL1 | |
| SCHEMBL22118433 | 0.86 | APOL1 (1.00) | APOL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252849-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |