Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 2/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 17/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24098887 | 0.86 | APOL1 (0.59) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24907079 | 0.85 | APOL1 (0.57) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24907063 | 0.85 | APOL1 (0.57) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24099388 | 0.85 | APOL1 (0.57) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24098976 | 0.85 | APOL1 (0.57) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24098982 | 0.85 | APOL1 (0.57) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24099357 | 0.84 | APOL1 (0.56) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24098696 | 0.84 | APOL1 (0.56) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24099293 | 0.84 | APOL1 (0.56) | APOL1CXCR2CYP2C9PPARG | |
| SCHEMBL24099481 | 0.84 | APOL1 (0.56) | APOL1CXCR2CYP2C9PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252849-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |