Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.61 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487408 | 0.84 | CDK2 (0.58) | CCNKDDB1CDK12SMN1; SMN2GABRA5 | |
| SCHEMBL24101425 | 0.84 | CCNK (0.66) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL27569408 | 0.81 | CCNE1 (0.53) | CCNKDDB1CDK12SMN1; SMN2GABRA5 | |
| SCHEMBL24101405 | 0.80 | CCNK (0.56) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL24101442 | 0.79 | CCNK (0.81) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL24101742 | 0.79 | CCNK (0.72) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL24101721 | 0.77 | CCNK (0.73) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL24101439 | 0.76 | CCNK (1.00) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL24101625 | 0.76 | CCNK (0.78) | CCNKDDB1CDK12SMN1; SMN2HTT | |
| SCHEMBL7845357 | 0.76 | GABRA5 (0.71) | SMN1; SMN2POLBGABRA5GABRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |