Known targets — ChEMBL curated mechanism
fasrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmB1rpmB2rpmCrpmDrpmErpmFrpmG1rpmG2rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsR1rpsR2rpsSrpsTrpsZ
The experimentally established mechanism targets of Pyrazinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazinamide SCHEMBL18364989 | 1.00 | — | — | |
| Pyrazinamide SCHEMBL18364990 | 1.00 | — | — | |
| Pyrazinamide SCHEMBL29408106 | 1.00 | — | — | |
| Pyrazinamide SCHEMBL18364991 | 1.00 | — | — | |
| Pyrazinamide SCHEMBL2433265 | 1.00 | ADORA3 (1.00) | — | |
| Pyrazinamide SCHEMBL29518620 | 1.00 | — | — | |
| Pyrazinamide SCHEMBL6162016 | 0.98 | ADORA3 (0.95) | — | |
| Pyrazinamide SCHEMBL5010455 | 0.98 | ADORA3 (0.95) | — | |
| Pyrazinamide SCHEMBL11617895 | 0.98 | ADORA3 (0.95) | — | |
| Pyrazinamide SCHEMBL32667957 | 0.98 | ADORA3 (0.95) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 28776 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122091700-A | Lithium ion battery and power utilization device | — | 2026-05-26 | — | — | CN | claimed |
| CN-117045657-B | Pharmaceutical composition and application thereof | Guangzhou Jiayue Pharmaceutical Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260137766-A1 | LIPOSOME FORMULATIONS FOR TREATMENT OF ACTIVE TUBERCULOSIS | ARCHIVEL FARMA S L (ES) | 2026-05-21 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-12616691-B2 | Use of fatty acid oxidation inhibitors as antimicrobials | WASHINGTON UNIVERSITY IN ST. LOUIS (US) | 2026-05-05 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| EP-4727950-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2026-04-22 | — | — | EP | claimed |
| EP-4531856-B1 | BRUTON'S KINASE INHIBITORS FOR THE TREATMENT OF A SUDDEN ALLERGIC REACTION | ALK ABELLO AS (DK) | 2026-04-22 | — | — | EP | claimed |
| EP-4729525-A1 | NEWLY SYNTHESIZED BORON-NITROGEN HETEROCYCLES AND THEIR CONJUGATES WITH PHARMACEUTICALLY UTILIZABLE SUBSTANCES | Julius-Maximilians-Universität Würzburg (DE) | 2026-04-22 | — | — | EP | claimed |
| EP-4723893-A2 | COMPOSITIONS AND METHODS TO MITIGATE PHYTOTOXIC EFFECTS OF AGRICHEMICALS | Ascribe Bioscience Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| WO-1993017671-A1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | STATENS SERUMINSTITUT (DK) | 1993-09-16 | — | — | WO | claimed |
| WO-1991005771-A1 | LIPOPHILIC ACYLPYRAZINAMIDE PRODRUGS | SCHREIER HANS (US) | 1991-05-02 | — | — | WO | claimed |
| EP-0305008-A2 | Tumor or cancer cell killing therapy and agents useful therefor | OXI-GENE, INC. (US) | 1989-03-01 | — | — | EP | claimed |
| CN-85102070-B | Transfer printing paper and transfer printing of textile material | 西柏地产有限公司 | 1988-11-30 | — | — | CN | claimed |
| CN-85102070-A | The transfer printing paper of textile material and transfer printing | — | 1987-01-24 | — | — | CN | claimed |
| US-4406755-A | Bright palladium electrodeposition | TECHNIC INC. (US) | 1983-09-27 | — | — | US | claimed |
| US-4167392-A | Transfer printing process for hydrophilic fibrous material or blends of hydrophilic and synthetic fibrous material, with reactive disperse dyes | CIBA-GEIGY AG (CH) | 1979-09-11 | — | — | US | claimed |
| US-4110237-A | Compositions containing a diazine and a halogen compound for catalyzing copper etching solutions | Tokai Denka Kabushiki Kaisha (JP) | 1978-08-29 | — | — | US | claimed |
| US-4093415-A | DYEING, OPTICAL BRIGHTENERS, CARRIERS | CIBA GEIGY AG (CH) | 1978-06-06 | — | — | US | claimed |
| US-3936332-A | DIAZINE, PEROXYSULFATE, HALOGEN COMPOUND | TOKAI DENKA KOGYO KABUSHIKI KAISHA (JA) | 1976-02-03 | — | — | US | claimed |