⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL28070874 | 0.97 | HDAC8 (0.33) | — | |
| Phosphine SCHEMBL29001674 | 0.97 | HDAC8 (0.33) | — | |
| SCHEMBL18762857 | 0.78 | — | — | |
| SCHEMBL11994398 | 0.77 | CYP2A6 (0.40) | — | |
| SCHEMBL24724749 | 0.75 | — | — | |
| SCHEMBL21031336 | 0.75 | — | — | |
| SCHEMBL21191727 | 0.75 | HDAC8 (0.32) | — | |
| SCHEMBL20567997 | 0.75 | — | — | |
| SCHEMBL22423794 | 0.75 | HDAC8 (0.32) | — | |
| SCHEMBL310530 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2461 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3998261-B1 | PYRIMIDIN-2-YLAMINO-1H-PYRAZOLS AS LRRK2 INHIBITORS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | DENALI THERAPEUTICS INC (US) | 2025-05-07 | — | — | EP | claimed |
| CN-104744376-A | Preparation method of 2-isopropyl pyrimidine derivative | CHANGSHA SHENCHENG BIOLOG TECHNOLOGY CO LTD | 2015-07-01 | — | — | CN | claimed |
| CN-103022556-A | Lithium-ion battery and electrolyte thereof | NINGDE AMPEREX TECHNOLOGY LTD | 2013-04-03 | — | — | CN | claimed |
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | claimed |
| US-20250129044-A1 | PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS | XENON PHARMACEUTICALS INC. (CA) | 2025-04-24 | — | — | US | disclosed |
| WO-2025027567-A1 | PROCESS FOR PREPARING MAVACAMTEN AND PROCESS INTERMEDIATE | OLON S.P.A. (IT) | 2025-02-06 | — | — | WO | disclosed |
| US-12202826-B2 | N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway | REDX PHARMA PLC (GB) | 2025-01-21 | — | — | US | disclosed |
| CN-119095609-A | Agent for eliminating obesity and composition for eliminating obesity | 丸善制药株式会社 | 2024-12-06 | — | — | CN | disclosed |
| US-12043607-B2 | HDAC inhibitors and therapeutic use thereof | TANGO THERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
| US-12043607-B2 | HDAC inhibitors and therapeutic use thereof | TANGO THERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
| CN-118359609-A | Heterocyclic compounds, their preparation and use | 益方生物科技(上海)股份有限公司 | 2024-07-19 | — | — | CN | disclosed |
| US-20240239777-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
| EP-0193973-A1 | Method of preparation of 2-alkylpyrimidine by dehydrogenation of 2-alkyltetrahydropyrimidine | THE DOW CHEMICAL COMPANY (US) | 1986-09-10 | — | — | EP | disclosed |
| EP-0192297-A1 | Process for the preparation of A 2-alkylpyrimidine | STAMICARBON B.V. (NL) | 1986-08-27 | — | — | EP | disclosed |
| US-4493929-A | Preparation of 2-alkylpyrimidines | THE DOW CHEMICAL COMPANY (US) | 1985-01-15 | — | — | US | disclosed |
| US-4474599-A | 1-(Pyridyl)-1H-1,2,3-triazole derivatives, and use as herbicidal agents | THE DOW CHEMICAL COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0117882-A1 | Novel aminopropylpivalamides and a method of preparation | THE DOW CHEMICAL COMPANY (US) | 1984-09-12 | — | — | EP | disclosed |
| US-4433037-A | WITH COBALT AMINE OXIDIZING AGENT AND COMPLEXING AGENT | EASTMAN KODAK COMPANY (US) | 1984-02-21 | — | — | US | disclosed |
| US-4055411-A | 5-NITRO-PYRIMIDINES | CIBA-GEIGY CORPORATION (US) | 1977-10-25 | — | — | US | disclosed |
| US-3948914-A | PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1976-04-06 | — | — | US | disclosed |