Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.30 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241029 | 0.97 | — | — | |
| Phosphine SCHEMBL29001674 | 0.94 | HDAC8 (0.33) | HDAC8HSP90AA1HTTGABRA1GABRB2 | |
| SCHEMBL18762857 | 0.75 | — | — | |
| SCHEMBL11994398 | 0.75 | CYP2A6 (0.40) | HTT | |
| SCHEMBL24724749 | 0.73 | — | — | |
| SCHEMBL21031336 | 0.73 | — | — | |
| SCHEMBL21191727 | 0.73 | HDAC8 (0.32) | HDAC8HSP90AA1CYP1A2 | |
| SCHEMBL22423794 | 0.73 | HDAC8 (0.32) | HDAC8HSP90AA1CYP1A2 | |
| SCHEMBL20567997 | 0.73 | — | — | |
| SCHEMBL18948130 | 0.73 | HDAC8 (0.32) | HDAC8HSP90AA1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814043-B | Triazolopyridine derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-05-17 | — | — | CN | disclosed |
| CN-105814049-B | Fused tricyclic imdazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-105814041-B | Benzotriazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-105814065-B | Imidazothiazole derivative as TNF active regulator | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105814058-B | Triazolo-pyridazine derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105814047-B | Fused tricyclic imdazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-10-19 | — | — | CN | disclosed |
| CN-105814025-B | Tetrahydrobenzimidazderivative derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-105814050-B | Pyrazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-05-08 | — | — | CN | disclosed |
| CN-105814048-B | Fused tricyclic benzimidizole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107787319-A | Indazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-105814065-A | Imidazothiazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814047-A | Fused tricyclic benzimidazoles derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814025-A | Tetrahydrobenzimidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814050-A | Pyrazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814049-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814043-A | Triazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814048-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814058-A | Triazolopyridazine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814045-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814060-A | Imidazotriazine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |