Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25447388 | 0.83 | TTK (0.40) | HRH3 | |
| SCHEMBL29106611 | 0.72 | TTK (0.38) | — | |
| SCHEMBL24104823 | 0.72 | TTK (0.40) | EGFRPTK2MAP4K1 | |
| SCHEMBL22124987 | 0.66 | PTK6 (0.48) | — | |
| SCHEMBL24104719 | 0.65 | TTK (0.44) | — | |
| SCHEMBL22124248 | 0.64 | PTK6 (0.45) | — | |
| SCHEMBL24105192 | 0.64 | PTK6 (0.47) | EGFRPTK2MAP4K1 | |
| SCHEMBL22124274 | 0.63 | PTK6 (0.48) | — | |
| SCHEMBL30178059 | 0.63 | PTK6 (0.48) | — | |
| SCHEMBL24104675 | 0.62 | PTK6 (0.50) | EGFRPTK2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249893-A1 | NOVEL IMIDAZO-PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |