Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 15/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24104823 | 0.89 | TTK (0.40) | TTKMAPKAPK5HTTPTK6 | |
| SCHEMBL29106611 | 0.89 | TTK (0.38) | TTK | |
| SCHEMBL24104719 | 0.83 | TTK (0.44) | TTKMAPKAPK5HTTPTK6 | |
| SCHEMBL22124987 | 0.83 | PTK6 (0.48) | TTKMAPKAPK5PTK6 | |
| SCHEMBL24104804 | 0.83 | EGFR (0.32) | HRH3 | |
| SCHEMBL22124248 | 0.81 | PTK6 (0.45) | TTKMAPKAPK5PTK6 | |
| SCHEMBL24105192 | 0.80 | PTK6 (0.47) | TTKPTK6 | |
| SCHEMBL24104978 | 0.79 | TTK (0.41) | TTKMAPKAPK5PTK6 | |
| SCHEMBL30177715 | 0.78 | TTK (0.49) | TTKMAPKAPK5PTK6 | |
| SCHEMBL24870844 | 0.77 | PTK6 (0.47) | TTKMAPKAPK5PTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | XDH, MYD88, IKZF3 | TTK 4157/4885MAPKAPK5 771/4885HTT 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.