Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.66 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.66 |
| ▸ | ITGB6 | P18564 | 10/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL275120 | 0.97 | ITGAV (0.62) | ITGAVITGB3ITGB6ITGA5ITGB1 | |
| SCHEMBL274666 | 0.94 | ITGAV (0.67) | ITGAVITGB3ITGB6ITGA5ITGB1 | |
| SCHEMBL276941 | 0.93 | ITGAV (0.58) | ITGAVITGB3ITGB6 | |
| SCHEMBL276261 | 0.87 | ITGAV (0.65) | ITGAVITGB3ITGB6ITGA5 | |
| SCHEMBL275899 | 0.86 | ITGAV (0.59) | ITGAVITGB3ITGB6ITGA5 | |
| SCHEMBL3741356 | 0.81 | ITGAV (0.61) | ITGAVITGB3ITGB6ITGA5 | |
| SCHEMBL6421344 | 0.80 | ITGAV (1.00) | ITGAVITGB3ITGB6 | |
| SCHEMBL6421342 | 0.80 | ITGAV (1.00) | ITGAVITGB3ITGB6 | |
| SCHEMBL13237151 | 0.80 | ITGAV (0.51) | ITGAVITGB3ITGB6ITGA5ITGB1 | |
| SCHEMBL2232146 | 0.80 | ITGAV (0.51) | ITGAVITGB3ITGB6ITGA5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747222-B1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | GALAPAGOS NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| EP-2368891-B1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | GALAPAGOS NV (BE) | 2012-09-19 | — | — | EP | disclosed |
| EP-2368891-A1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | Galapagos SAS (FR) | 2011-09-28 | — | — | EP | disclosed |
| EP-1747222-A1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | Proskelia SAS (FR) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005123734-A1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | PROSKELIA SAS (FR) | 2005-12-29 | — | — | WO | disclosed |