Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.57 |
| ▸ | ATP4A | P20648 | 5/20 | 0.36 |
| ▸ | ATP4B | P51164 | 5/20 | 0.36 |
| ▸ | NCF1 | P14598 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYBB | P04839 | 1/20 | 0.31 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24112048 | 0.93 | ERBB2 (0.65) | ERBB2MINK1ATP4AATP4BMAPT | |
| SCHEMBL26316884 | 0.92 | ERBB2 (0.52) | ERBB2MINK1ATP4AATP4BMAPT | |
| SCHEMBL26316579 | 0.92 | ERBB2 (0.69) | ERBB2MINK1ATP4AATP4BNCF1 | |
| SCHEMBL24112051 | 0.90 | ERBB2 (0.54) | ERBB2MINK1NCF1MAPTGRM5 | |
| SCHEMBL24112017 | 0.90 | ERBB2 (0.50) | ERBB2MINK1MAPTGRM5SMN1; SMN2 | |
| SCHEMBL26316603 | 0.90 | ERBB2 (0.52) | ERBB2MINK1MAPT | |
| SCHEMBL26316601 | 0.89 | ERBB2 (0.51) | ERBB2MINK1MAPTSMN1; SMN2 | |
| SCHEMBL24112070 | 0.89 | ERBB2 (0.56) | ERBB2MINK1MAPTGRM5 | |
| SCHEMBL22398129 | 0.88 | ERBB2 (0.66) | ERBB2MINK1ATP4AATP4BNCF1 | |
| SCHEMBL28900623 | 0.84 | ERBB2 (0.66) | ERBB2MINK1ATP4AATP4BNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2021-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, IDH1 | ERBB2 2558/4885MINK1 1781/4885ATP4A 1129/4885 |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, NUTF2 | ERBB2 2443/4885MINK1 1986/4885ATP4A 1802/4885 |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | IDH2, TFAM, NUTF2 | ERBB2 2443/4885MINK1 1986/4885ATP4A 1802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.