Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24112177 | 1.00 | MAPK1 (0.39) | MAPK1IDH1GRIA2ENPP2HDAC8 | |
| SCHEMBL30724675 | 0.83 | HDAC8 (0.47) | MAPK1IDH1GRIA2ENPP2HDAC8 | |
| SCHEMBL28925378 | 0.82 | GRIA2 (0.38) | MAPK1IDH1GRIA2ENPP2HDAC8 | |
| SCHEMBL22057917 | 0.81 | ENPP2 (0.48) | ENPP2GBA1 | |
| SCHEMBL29771574 | 0.81 | ENPP2 (0.48) | ENPP2GBA1 | |
| SCHEMBL22092783 | 0.81 | ENPP2 (0.41) | IDH1ENPP2HDAC8HDAC6 | |
| SCHEMBL22092784 | 0.81 | ENPP2 (0.41) | IDH1ENPP2HDAC8HDAC6 | |
| SCHEMBL22092898 | 0.81 | IDH1 (0.39) | MAPK1IDH1GRIA2ENPP2HDAC8 | |
| SCHEMBL28647967 | 0.81 | IDH1 (0.39) | MAPK1IDH1GRIA2ENPP2HDAC8 | |
| SCHEMBL23519728 | 0.80 | HDAC8 (0.38) | MAPK1ENPP2HDAC8HDAC6GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230112172-A1 | SUBSTITUED AMINO-PYRIMIDINES | HOFFMANN-LA ROCHE INC. (US) | 2023-04-13 | — | — | US | disclosed |
| US-20230112172-A1 | SUBSTITUED AMINO-PYRIMIDINES | HOFFMANN-LA ROCHE INC. (US) | 2023-04-13 | — | — | US | disclosed |
| CN-115551844-A | Substituted amino-pyrimidines | 豪夫迈·罗氏有限公司 | 2022-12-30 | — | — | CN | disclosed |
| WO-2021249892-A1 | SUBSTITUTED AMINO-PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230112172-A1 | SUBSTITUED AMINO-PYRIMIDINES | TYMS, TYMP, HPRT1 | MAPK1 2984/4885IDH1 406/4885GRIA2 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.